Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rat and human
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چکیده
Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China (A.Z., C.W., Q.L., Q.M., J.P., H.S., X.M., X.H., K.L) Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China (C.W., Q.L., Q.M., J.P., H.S., X.M., K.L) Research Institute of Integrated Traditional and Western Medicine of Dalian Medical University, Liaoning, China (J.P., X.M., K.L) DMD Fast Forward. Published on February 8, 2013 as doi:10.1124/dmd.112.049452
منابع مشابه
Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans.
The objective of this study was to clarify the mechanism underlying hepatic uptake of dioscin (diosgenyl 2,4-di-O-a-L-rhamnopyranosyl-p-D-glucopyranoside), an herbal ingredient with antihepatitis activity, in rats and humans. The liver uptake index (LUI) in vivo, perfused rat liver in situ, rat liver slices, isolated rat hepatocytes, and human organic anion-transporting polypeptide (OATP)-trans...
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Hepatic uptake of albumin-bound amphipathic organic cations has been suggested to be mediated by multispecific bile salt and organic anion transport systems. Therefore, we investigated whether the recently cloned rat organic anion transporting polypeptides 1 and 2 as well as the human organic anion transporting polypeptide might be involved in the hepatocellular uptake of bulky type II organic ...
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BACKGROUND & AIMS Cholecystokinin (CCK) is a major gastrointestinal peptide hormone that is released postprandially from the small intestine and exerts marked effects on gallbladder and gastrointestinal motility. The smaller isoforms CCK-8 and CCK-4 are rapidly taken up into hepatocytes, metabolized, and excreted into bile. Our aim was to identify and characterize the hepatocellular CCK-8 uptak...
متن کاملFunctional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions.
Our previous kinetic analyses have shown that the transporter responsible for the renal uptake of pravastatin, an HMG-CoA reductase inhibitor, differs from that involved in its hepatic uptake. Although organic anion transporting polypeptides are now known to be responsible for the hepatic uptake of pravastatin, the renal uptake mechanism has not been clarified yet. In the present study, the inv...
متن کاملImpaired Hepatic Uptake by Organic Anion-Transporting Polypeptides Is Associated with Hyperbilirubinemia and Hypercholanemia in Atp11c Mutant Mice.
Biliary excretion of organic anions, such as bile acids (BAs), is the main osmotic driving force for bile formation, and its impairment induces intrahepatic cholestasis. We investigated the involvement of Atp11c in the hepatic transport of organic anions using Atp11c mutant mice, which exhibit hypercholanemia and hyperbilirubinemia. Pharmacokinetic analysis following a constant intravenous infu...
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تاریخ انتشار 2013